Stadium: Daytona Stadium Round: 1
Home Manager: Raymond Woodie Away Manager: Kendrick Wade
| NCAAF | 2022/10/22 20:00 | Bethune Cookman v Mississippi Valley State | L | 45-35 |
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | W | 20-14 |
| NCAAF | 2019/09/21 23:00 | Bethune Cookman v Mississippi Valley State | L | 22-6 |
| NCAAF | 2018/10/06 20:00 | Mississippi Valley State v Bethune Cookman | L | 27-41 |