Southern Illinois 63-0 Western Illinois 2023-10-28 20:00
Stadium: Hanson Field Round: 1
Home Manager: Myers Hendrickson Away Manager: Nick Hill
Head to Head
| NCAAF | 2022/10/15 19:00 | Western Illinois v SO Illinois | W | 7-30 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2019/11/16 19:00 | SO Illinois v Western Illinois | W | 45-21 |
| NCAAF FCS | 2018/11/03 18:00 | Western Illinois v SO Illinois | L | 34-31 |
| NCAAF | 2017/11/18 19:00 | Western Illinois v SO Illinois | L | 28-14 |