[7] Santos Laguna 3-1 Tigres [9] 2018-08-19 23:00
Stadium: Estadio TSM Corona Round: 5
Referee: Jorge Antonio Perez Duran Home Manager: Salvador Reyes Away Manager: Ricardo Ferretti
Head to Head
| Mexico Champion of Champions | 2018/07/16 01:00 | Tigres UANL v Santos Laguna | L | 4-0 |
| Mexico Liga MX | 2018/05/06 23:00 | Santos Laguna v Tigres UANL | W | 2-0 |
| Mexico Liga MX | 2018/05/04 00:30 | Tigres UANL v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2018/01/14 01:00 | Tigres UANL v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2017/07/30 23:30 | Santos Laguna v Tigres UANL | D | 1-1 |
| Mexico Liga MX | 2017/01/08 01:00 | Tigres UANL v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2016/07/17 23:00 | Santos Laguna v Tigres UANL | D | 0-0 |
| Mexico Liga MX | 2016/04/24 00:00 | Santos Laguna v Tigres UANL | W | 2-1 |
| Mexico Liga MX | 2015/11/01 01:00 | Tigres UANL v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2015/05/17 00:00 | Tigres UANL v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2015/05/14 00:00 | Santos Laguna v Tigres UANL | D | 1-1 |
| Mexico Liga MX | 2015/03/21 03:30 | Santos Laguna v Tigres UANL | D | 2-2 |
| Mexico Cup | 2014/10/30 03:00 | Tigres UANL v Santos Laguna | W | 2-4 |
| Mexico Liga MX | 2014/10/01 02:00 | Tigres UANL v Santos Laguna | D | 1-1 |