Central Michigan 20-31 Michigan State 2018-09-29 16:00
Stadium: Spartan Stadium Round: 1
Home Manager: Mark Dantonio Away Manager: John Bonamego
Head to Head
| NCAAF | 2015/09/26 16:00 | Michigan State v Central Michigan | L | 30-10 |
| NCAAF | 2012/09/08 12:00 | Central Michigan v Michigan State | L | 7-41 |
| NCAAF | 2011/09/24 12:00 | Michigan State v Central Michigan | L | 45-7 |
| NCAAF | 2009/09/12 12:00 | Michigan State v Central Michigan | W | 27-29 |
| NCAAF | 2004/09/11 12:00 | Michigan State v Central Michigan | L | 24-7 |
| NCAAF | 2001/09/08 12:00 | Michigan State v Central Michigan | L | 35-21 |