[5] Santos Laguna 3-0 Puebla [3] 2021-05-21 02:00
Stadium: Estadio TSM Corona Round: 2
Referee: Marco Antonio Ortiz Nava Home Manager: Guillermo Almada Away Manager: Nicolas Larcamon
Head to Head
| Mexico Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |
| Mexico Liga MX | 2020/10/03 00:30 | Puebla v Santos Laguna | W | 0-2 |
| Mexico Liga MX | 2020/02/08 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2019/08/11 23:45 | Santos Laguna v Puebla | W | 4-1 |
| Mexico Liga MX | 2019/01/19 03:00 | Puebla v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/08/05 23:00 | Santos Laguna v Puebla | W | 2-0 |
| Mexico Liga MX | 2018/03/17 01:00 | Puebla v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2017/10/01 23:30 | Santos Laguna v Puebla | D | 0-0 |
Home History
| Mexico Liga MX | 2021/05/16 23:00 | Monterrey v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | W | 2-1 |
| Mexico Liga MX | 2021/05/09 02:15 | Santos Laguna v Queretaro | W | 5-0 |
| Mexico Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |
| Mexico Liga MX | 2021/04/27 02:00 | Pachuca v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/04/19 00:00 | Santos Laguna v Toluca | W | 3-1 |
| Mexico Liga MX | 2021/04/12 00:00 | Queretaro v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/04/04 22:00 | Chivas Guadalajara v Santos Laguna | D | 1-1 |
Away History
| Mexico Liga MX | 2021/05/15 23:00 | Puebla v Atlas | W | 1-0 |
| Mexico Liga MX | 2021/05/13 02:05 | Atlas v Puebla | L | 1-0 |
| Mexico Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |
| Mexico Liga MX | 2021/04/24 00:30 | Puebla v Unam Pumas | D | 0-0 |
| Mexico Liga MX | 2021/04/17 22:00 | Atletico San Luis v Puebla | W | 1-4 |
| Mexico Liga MX | 2021/04/13 02:00 | Pachuca v Puebla | W | 1-3 |
| Mexico Liga MX | 2021/04/03 01:30 | Puebla v Mazatlan FC | W | 3-1 |
| Mexico Liga MX | 2021/03/21 18:00 | Toluca v Puebla | D | 4-4 |