[5] Santos Laguna 3-0 Puebla [3] 2021-05-21 02:00
Stadium: Estadio TSM Corona Round: 2
Referee: Marco Antonio Ortiz Nava Home Manager: Guillermo Almada Away Manager: Nicolas Larcamon
Head to Head
| Mexico Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |
| Mexico Liga MX | 2020/10/03 00:30 | Puebla v Santos Laguna | W | 0-2 |
| Mexico Liga MX | 2020/02/08 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2019/08/11 23:45 | Santos Laguna v Puebla | W | 4-1 |
| Mexico Liga MX | 2019/01/19 03:00 | Puebla v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/08/05 23:00 | Santos Laguna v Puebla | W | 2-0 |
| Mexico Liga MX | 2018/03/17 01:00 | Puebla v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2017/10/01 23:30 | Santos Laguna v Puebla | D | 0-0 |
| Mexico Liga MX | 2017/01/30 00:00 | Santos Laguna v Puebla | W | 2-0 |
| Mexico Liga MX | 2016/08/07 23:00 | Puebla v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2016/02/28 01:00 | Santos Laguna v Puebla | D | 1-1 |
| Mexico Liga MX | 2015/09/13 22:00 | Puebla v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2015/05/10 01:30 | Santos Laguna v Puebla | D | 2-2 |
| Mexico Liga MX | 2014/11/22 23:00 | Puebla v Santos Laguna | D | 3-3 |
| Mexico Cup | 2014/11/05 03:00 | Santos Laguna v Puebla | W | 4-2 |