Head to Head
| NFL | 2022/11/24 17:30 | BUF Bills v DET Lions | W | 28-25 |
| NFL Preseason | 2021/08/13 23:00 | BUF Bills v DET Lions | W | 16-15 |
| NFL Preseason | 2019/08/24 00:00 | BUF Bills v DET Lions | W | 24-20 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| NFL Preseason | 2017/08/31 23:00 | BUF Bills v DET Lions | W | 27-17 |
| NFL Preseason | 2016/09/01 23:30 | DET Lions v BUF Bills | L | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | W | 14-17 |
Home History
| NFL | 2024/12/08 21:25 | BUF Bills v LA Rams | L | 42-44 |
| NFL | 2024/12/02 01:20 | SF 49ers v BUF Bills | W | 10-35 |
| NFL | 2024/11/17 21:25 | KC Chiefs v BUF Bills | W | 21-30 |
| NFL | 2024/11/10 18:00 | BUF Bills v IND Colts | W | 30-20 |
| NFL | 2024/11/03 18:00 | MIA Dolphins v BUF Bills | W | 27-30 |
| NFL | 2024/10/27 20:05 | BUF Bills v SEA Seahawks | W | 31-10 |
| NFL | 2024/10/20 17:00 | TEN Titans v BUF Bills | W | 10-34 |
| NFL | 2024/10/15 00:15 | BUF Bills v NY Jets | W | 23-20 |
Away History
| NFL | 2024/12/06 01:15 | GB Packers v DET Lions | W | 31-34 |
| NFL | 2024/11/28 17:30 | CHI Bears v DET Lions | W | 20-23 |
| NFL | 2024/11/24 18:00 | DET Lions v IND Colts | W | 24-6 |
| NFL | 2024/11/17 18:00 | JAX Jaguars v DET Lions | W | 6-52 |
| NFL | 2024/11/11 01:20 | DET Lions v HOU Texans | W | 26-23 |
| NFL | 2024/11/03 21:25 | DET Lions v GB Packers | W | 24-14 |
| NFL | 2024/10/27 17:00 | TEN Titans v DET Lions | W | 14-52 |
| NFL | 2024/10/20 17:00 | DET Lions v MIN Vikings | W | 31-29 |